Measured Creatinine Clearance
Calculates creatinine clearance from a collected urine sample and serum creatinine.
When to use
Glomerular filtration estimate with a timed urine collection when equation-based estimates are unreliable.
Pearls and pitfalls
- The collection must be timed and complete; lost volume underestimates clearance.
- Urine and serum creatinine must use the same mass per volume unit.
- Creatinine is filtered and also secreted, which can overestimate filtration in some patients.
- Do not adjust the result for body surface area without recording the decision.
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Formula
Clearance (mL/min) = urine creatinine × urine volume / (serum creatinine × collection duration in minutes).
Evidence
Classic method for measuring creatinine clearance with a timed urine collection.
References
- National Kidney Foundation. KDIGO 2012 Clinical Practice Guideline for the Evaluation and Management of Chronic Kidney Disease. Kidney Int Suppl. 2013;3(1):1-150. https://kdigo.org/guidelines/ckd-evaluation-and-management/
Frequently asked questions
What is Measured Creatinine Clearance?
Calculates creatinine clearance from a collected urine sample and serum creatinine. Glomerular filtration estimate with a timed urine collection when equation-based estimates are unreliable.
How is the result calculated?
Clearance (mL/min) = urine creatinine × urine volume / (serum creatinine × collection duration in minutes).
How should the result be interpreted?
Classic method for measuring creatinine clearance with a timed urine collection.
What are the sources?
National Kidney Foundation. KDIGO 2012 Clinical Practice Guideline for the Evaluation and Management of Chronic Kidney Disease. Kidney Int Suppl. 2013;3(1):1-150.