MDRD Creatinine Clearance
Estimates glomerular filtration from creatinine, age, sex and race in the MDRD equation.
When to use
Historical estimate of glomerular filtration in adults when the MDRD equation is requested instead of CKD-EPI.
Pearls and pitfalls
- The equation uses creatinine in mg/dL, age in years and coefficients for female sex and Black race.
- The race coefficient was removed from current equations for lack of biological justification and risk of error.
- The estimate is less accurate at extremes of muscle mass, amputation, pregnancy and acute kidney injury.
- Stages G1 and G2 do not define chronic kidney disease without a damage marker.
Fill in the fields to see the result.
Formula
GFR = 175 × creatinine^-1.154 × age^-0.203 × 0.742 if female × 1.212 if Black race.
Evidence
Four variable equation derived in the Modification of Diet in Renal Disease Study and re-expressed for IDMS standardized creatinine.
References
- Levey AS, Bosch JP, Lewis JB, Greene T, Rogers N, Roth D. A more accurate method to estimate glomerular filtration rate from serum creatinine: a new prediction equation. Ann Intern Med. 1999;130(6):461-470. doi:10.7326/0003-4819-130-6-199903160-00002
- Levey AS, Coresh J, Greene T, et al. Using standardized serum creatinine values in the modification of diet in renal disease study equation for estimating glomerular filtration rate. Ann Intern Med. 2006;145(4):247-254. doi:10.7326/0003-4819-145-4-200608150-00004
Frequently asked questions
What is MDRD Creatinine Clearance?
Estimates glomerular filtration from creatinine, age, sex and race in the MDRD equation. Historical estimate of glomerular filtration in adults when the MDRD equation is requested instead of CKD-EPI.
How is the result calculated?
GFR = 175 × creatinine^-1.154 × age^-0.203 × 0.742 if female × 1.212 if Black race.
How should the result be interpreted?
Four variable equation derived in the Modification of Diet in Renal Disease Study and re-expressed for IDMS standardized creatinine.
What are the sources?
Levey AS, Bosch JP, Lewis JB, Greene T, Rogers N, Roth D. A more accurate method to estimate glomerular filtration rate from serum creatinine: a new prediction equation. Ann Intern Med. 1999;130(6):461-470. Levey AS, Coresh J, Greene T, et al. Using standardized serum creatinine values in the modification of diet in renal disease study equation for estimating glomerular filtration rate. Ann Intern Med. 2006;145(4):247-254.