DAS-28 with CRP (Rheumatoid Arthritis)
Measures rheumatoid arthritis activity with 28 joints, CRP and global assessment.
When to use
Adults with rheumatoid arthritis to measure activity when CRP is preferred to ESR.
Pearls and pitfalls
- DAS-28 with CRP uses the same 28 joints and the 100 mm global assessment.
- The formula uses ln(CRP + 1) and adds a constant of 0.96.
- The cutoffs are the same: remission below 2.6 and high activity above 5.1.
- The CRP and ESR scores are not interchangeable within the same follow-up series.
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Formula
DAS28-CRP = 0.56 × √tender joints + 0.28 × √swollen joints + 0.36 × ln(CRP + 1) + 0.014 × global assessment + 0.96.
Evidence
Disease activity index derived and validated in rheumatoid arthritis, with remission and activity cutoffs.
References
- Prevoo ML, van 't Hof MA, Kuper HH, van Leeuwen MA, van de Putte LB, van Riel PL. Modified disease activity scores that include twenty-eight-joint counts. Arthritis Rheum. 1995;38(1):44-48. doi:10.1002/art.1780380107
Frequently asked questions
What is DAS-28 with CRP (Rheumatoid Arthritis)?
Measures rheumatoid arthritis activity with 28 joints, CRP and global assessment. Adults with rheumatoid arthritis to measure activity when CRP is preferred to ESR.
How is the result calculated?
DAS28-CRP = 0.56 × √tender joints + 0.28 × √swollen joints + 0.36 × ln(CRP + 1) + 0.014 × global assessment + 0.96.
How should the result be interpreted?
Disease activity index derived and validated in rheumatoid arthritis, with remission and activity cutoffs.
What are the sources?
Prevoo ML, van 't Hof MA, Kuper HH, van Leeuwen MA, van de Putte LB, van Riel PL. Modified disease activity scores that include twenty-eight-joint counts. Arthritis Rheum. 1995;38(1):44-48.