AST to Platelet Ratio Index
Estimates fibrosis and cirrhosis in chronic hepatitis C using AST and platelets.
When to use
Adults with chronic hepatitis C for noninvasive fibrosis stratification.
Pearls and pitfalls
- APRI uses AST divided by its upper limit and by platelets.
- Values below 0.5 make significant fibrosis unlikely; above 1.5 make it likely.
- Values above 2 suggest cirrhosis in the original study.
- The index was derived in hepatitis C and may perform differently in other liver diseases.
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Formula
APRI = (AST ÷ AST upper limit) ÷ platelets (10³/µL) × 100.
Evidence
Noninvasive index derived to predict significant fibrosis and cirrhosis in chronic hepatitis C.
References
- Wai CT, Greenson JK, Fontana RJ, et al. A simple noninvasive index can predict both significant fibrosis and cirrhosis in patients with chronic hepatitis C. Hepatology. 2003;38(2):518-526. doi:10.1053/jhep.2003.50346
Frequently asked questions
What is AST to Platelet Ratio Index?
Estimates fibrosis and cirrhosis in chronic hepatitis C using AST and platelets. Adults with chronic hepatitis C for noninvasive fibrosis stratification.
How is the result calculated?
APRI = (AST ÷ AST upper limit) ÷ platelets (10³/µL) × 100.
How should the result be interpreted?
Noninvasive index derived to predict significant fibrosis and cirrhosis in chronic hepatitis C.
What are the sources?
Wai CT, Greenson JK, Fontana RJ, et al. A simple noninvasive index can predict both significant fibrosis and cirrhosis in patients with chronic hepatitis C. Hepatology. 2003;38(2):518-526.