NAFLD Fibrosis Score
Estimates advanced fibrosis in nonalcoholic fatty liver disease without biopsy.
When to use
Adults with nonalcoholic fatty liver disease to stratify advanced fibrosis noninvasively.
Pearls and pitfalls
- The score combines age, BMI, glucose status, AST/ALT ratio, platelets and albumin.
- Values below -1.455 make advanced fibrosis unlikely; values above 0.675 make it likely.
- The indeterminate range does not exclude fibrosis and usually requires elastography or biopsy.
- The score was derived in cohorts with confirmed NAFLD and does not replace clinical assessment.
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Formula
Score = -1.675 + 0.037 × age + 0.094 × BMI + 1.13 × (impaired fasting glucose or diabetes) + 0.99 × AST/ALT - 0.013 × platelets - 0.66 × albumin.
Evidence
Noninvasive system derived and validated in patients with NAFLD to identify advanced fibrosis.
References
- Angulo P, Hui JM, Marchesini G, et al. The NAFLD fibrosis score: a noninvasive system that identifies liver fibrosis in patients with NAFLD. Hepatology. 2007;45(4):846-854. doi:10.1002/hep.21496
Frequently asked questions
What is NAFLD Fibrosis Score?
Estimates advanced fibrosis in nonalcoholic fatty liver disease without biopsy. Adults with nonalcoholic fatty liver disease to stratify advanced fibrosis noninvasively.
How is the result calculated?
Score = -1.675 + 0.037 × age + 0.094 × BMI + 1.13 × (impaired fasting glucose or diabetes) + 0.99 × AST/ALT - 0.013 × platelets - 0.66 × albumin.
How should the result be interpreted?
Noninvasive system derived and validated in patients with NAFLD to identify advanced fibrosis.
What are the sources?
Angulo P, Hui JM, Marchesini G, et al. The NAFLD fibrosis score: a noninvasive system that identifies liver fibrosis in patients with NAFLD. Hepatology. 2007;45(4):846-854.