Sokal Index for CML
Estimates chronic myeloid leukemia risk using age, spleen, platelets and blasts.
When to use
Adults with chronic myeloid leukemia for initial prognostic stratification.
Pearls and pitfalls
- The index uses age, spleen size, platelets and blast percentage.
- Values below 0.8 indicate low risk; above 1.2, high risk.
- The formula uses the square of the platelet count divided by 700.
- Sokal predates tyrosine kinase inhibitors and should be interpreted in the current context.
Fill in the fields to see the result.
Formula
Sokal = exp[0.0116 × (age − 43.4) + 0.0345 × (spleen − 7.51) + 0.188 × ((platelets/700)² − 0.563) + 0.0887 × (blasts − 2.10)].
Evidence
Index derived in a chronic myeloid leukemia cohort to discriminate survival.
References
- Sokal JE, Cox EB, Baccarani M, et al. Prognostic discrimination in "good-risk" chronic granulocytic leukemia. Blood. 1984;63(4):789-799. https://pubmed.ncbi.nlm.nih.gov/6703814/
Frequently asked questions
What is Sokal Index for CML?
Estimates chronic myeloid leukemia risk using age, spleen, platelets and blasts. Adults with chronic myeloid leukemia for initial prognostic stratification.
How is the result calculated?
Sokal = exp[0.0116 × (age − 43.4) + 0.0345 × (spleen − 7.51) + 0.188 × ((platelets/700)² − 0.563) + 0.0887 × (blasts − 2.10)].
How should the result be interpreted?
Index derived in a chronic myeloid leukemia cohort to discriminate survival.
What are the sources?
Sokal JE, Cox EB, Baccarani M, et al. Prognostic discrimination in "good-risk" chronic granulocytic leukemia. Blood. 1984;63(4):789-799.