Follicular Lymphoma International Prognostic Index
Estimates follicular lymphoma prognosis with five clinical factors.
When to use
Adults with follicular lymphoma, to stratify prognosis and support treatment decisions.
Pearls and pitfalls
- FLIPI uses age, stage, hemoglobin, LDH and number of nodal areas.
- Zero or one factor indicates low risk; three or more indicate high risk.
- The index predates modern therapies and should be interpreted in the current context.
- FLIPI does not replace clinical assessment, staging and disease biology.
0/5 factors
Low risk
Use the index with stage, symptoms and preferences in planning.
Formula
Add 1 point for each factor: age above 60, stage III or IV, hemoglobin below 12 g/dL, elevated LDH and more than 4 nodal areas.
Evidence
Index derived in an international follicular lymphoma cohort to predict overall survival.
References
- Solal-Celigny P, Roy P, Colombat P, et al. Follicular lymphoma international prognostic index. Blood. 2004;104(5):1258-1265. doi:10.1182/blood-2003-12-4247
Frequently asked questions
What is Follicular Lymphoma International Prognostic Index?
Estimates follicular lymphoma prognosis with five clinical factors. Adults with follicular lymphoma, to stratify prognosis and support treatment decisions.
How is the result calculated?
Add 1 point for each factor: age above 60, stage III or IV, hemoglobin below 12 g/dL, elevated LDH and more than 4 nodal areas.
How should the result be interpreted?
Index derived in an international follicular lymphoma cohort to predict overall survival.
What are the sources?
Solal-Celigny P, Roy P, Colombat P, et al. Follicular lymphoma international prognostic index. Blood. 2004;104(5):1258-1265.